Businessweek.com worked with Seattle’s Payscale.com to determine where the best and worst cities are for 20 common careers and found that — when it comes to earning a comfortable living — Houston it at or near the top for most jobs, from human resources manager to graphic designer. We adjusted the median compensation for jobs in each of the top 25 big-city metros for cost of living. Houston, Dallas, and Charlotte, N.C., rose to the top for many of the jobs because they’re affordable cities with competitive salaries. New York, San Francisco, Washington, Los Angeles, and Boston, which have some of the highest salaries, sank to the bottom because residents there pay through the nose for real estate, parking, groceries, and almost everything else.